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There is no evidence that the concentrations of estradiol or other estrogens in serum differ in male and female fetuses. The male sex organs work together to produce and release semen into the reproductive system of the female during sexual intercourse. Puberty tends to be regarded as a set of physical changes arising from reactivation of the hypothalamic-pituitary-gonadotropin-gonadal apparatus the feedback system integrating nervous and hormonal signals in the hypothalamus.
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A careful review of U. Prepubertal girls have a mean estradiol concentration of 0.
In girls as will be discussed below the onset of puberty, in retrospect, is marked by an increase in the growth rate even before breast development. Boys also undergo a growth spurt during puberty as they reach their adult height and weight.